PerkinElmer Life Sciences

Key Bio Nano Consulting Partner Develops Nanolitre Scale Technique for Determining Protein Stability and Ligand-Binding Affinity
BNC to provide commercial access to new technique enabling evaluation of low expressing proteins without the need for fluorescent tags.

Nature Medicine Publishes AVI BioPharma Preclinical Studies
Study demonstrates post-exposure efficacy of PMOplus™ Oligomers against Ebola and Marburg Viruses.

Agilent and Johns Hopkins to Research Toxicity Pathways for Embryonic Brain Development Using Metabolomics
The work could help identify possible contributions of chemicals to disorders such as autism and attention hyperactivity disorders.

Clavis Recruits First Patient in Pivotal Phase III Study of Elacytarabine in Late-Stage Acute Myeloid Leukaemia
Clinical trial aims to confirm significant survival benefit seen in Phase II.

Midatech and Monosol Rx Announce Filing of Joint Patent Application for Nanoparticle Film Delivery Systems
The applications submitted to USPTO relate to therapeutic uses of nanoparticle-based proteins and peptides delivered in pharmaceutical films.

High-Throughput Multiplexed Assay for Analysis of Hematopoietic Stem Cells Differentiation and Hematopoietic Toxicity
Molecular Devices

Hematopoietic stem cells (HSCs) give rise to all the blood cell types and are important for cell therapy and drug development. During the development of lymphoid and myeloid lineages, HSC differentiate into committed hematopoietic progenitors. Monitoring the expansion and differentiation of HSCs into lineage-commited hematopoietic progenitors is important for research of hematopoiesis and developing therspeutic processes with HSCs

The Transcreener® ADP2 Universal Kinase Assay from BellBrook Labs is readily performed on BMG LABTECH microplate readers using different assay formats
BMG LABTECH

The Transcreener® ADP2 FI assay kit from BellBrook Labs is a simple one-step competitive red fluorescence immunoassay based on the detection of ADP. In this application note we show that this assay is compatible with four different microplate readers from BMG LABTECH. With the PHERAstar FS and Plus, as well as the POLARstar and FLUOstar Omegas comparable standard curves and EC50 values were obtained.

Protein NMR/Biophysics Research Associate (BS/MS)
Novartis Institutes for BioMedical Research
We are committed to discovering innovative medicines to cure disease and improve human health. By hiring the best academic, biotech, and pharmaceutical trained scientists, we have fostered an atmosphere for drug discovery where innovation is rewarded.

Senior Account Manager/Account Director
Alto Marketing
The best career move for a well-connected marketing professional with real leadership ability and drive!

Senior Scientific Marketing Writer - Life Sciences
Alto Marketing
For a challenging career using your advanced life science background and writing strengths, please read on.

Post-doctoral position at INRA (France)
INRA
An 18-month post-doctoral position is available at INRA Clermont-Ferrand-Theix (France).The position is opened to both French and foreign applicants.

Engineer Technician, Fayetteville, Arizona, USA
SFC-Fluidics
SFC Fluidics is looking to hire a highly motivated, detail-oriented engineer technician.

oral communication skills . Experience with GMP and GLP desired

Computational Medicinal Chemistry Post-Doc Position, Siena, Italy
University of Siena
NatSynDrugs Is Seeking Candidates For a Computational Medicinal Chemistry Post-Doc Position

Automation Engineer, Metabolism, Agios Pharmaceuticals, Cambridge, MA, USA
Agios Pharmaceuticals
With new research showing that cancer cells become addicted to using more nutrients than normal cells to promote their rapid growth, there is an unprecedented opportunity to create a new class of oncology therapeutics that target a fundamental and ubiquitous mechanism in cancer cells. The intersection of these two fields of research - cancer and metabolism- represents an important and novel approach to treating cancer.


Senior Scientist, Metabolism
Agios
Agios Pharmaceuticals is seeking a PhD Scientist to join a team that is building and applying a state-of-art approach to investigate the intersection of cancer cell biology and metabolism.




Metabolomics Platform Coordinator, CIBERDEM, Barcelona
CIBERDEM
The Metabolomics Platform is a research facility financed by CIBERDEM, the Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders. CIBERDEM is an initiative of the Carlos III Health Institute (Ministry of Science and Innovation, http://www.isciii.es), while the platform is located at the Universitat Rovira i Virgili (Tarragona, Spain).

Senior Fellow, Long Term Research in Metabolomics and Nutrient
PepsiCo
Establish and lead the LTR Pepsico Biology Innovation Lab (PIBL) Metabolomics and Nutrient Physiology research program and team.

US Field Application Scientist, Cell based assay technology
Langton Howarth
Our client supplies novel laboratory scale instrumentation, screening services and develops custom automation for life sciences companies spanning the healthcare, biotech and pharmaceutical sectors.
Due to expansion they now seek a US Field Application Scientist to support sales and customers of their high content screening/cell based assay technology.

Compound Management Technologist, St Jude Children's Research Hospital, Memphis, TN

St. Jude Children's Research Hospital, located in Memphis, Tennessee, is a premier center for research and treatment of potentially fatal childhood diseases, including cancer and certain blood, genetic, and immunodeficiency disorders. The hospital's mission is to advance cures, and means of prevention, for pediatric catastrophic diseases through research and treatment. St. Jude is dedicated to providing unsurpassed patient care and to advancing the health of children through biomedical research.

Postdoctoral Research Associate
Northeastern University
The Center for Drug Discovery at Northeastern University is dedicated to designing and discovering novel medications, developing technologies, and training scientists in the multidisciplinary field of drug discovery. We are recruiting a Postdoctoral Research Associate with expertise in protein-based mass spectrometry and /or proteomics.

Discovery Summit 2010
19 September 2010 - 21 September 2010

The Discovery Summit offers unique format for solution providers to gain access to the leading senior drug discovery executives across North America. Solution providers will meet and interact with senior drug discovery executives through a number of one-to-one business meetings.

MipTec 2010, September 21 – 24, 2010, Basel, Switzerland
21 September 2010 - 24 September 2010

Please join us for THE European conference on Life Science and Biomedical Research. The program covers key topics and the latest breakthroughs in the fields of drug discovery. Whether you work in academia, pharma, or life science technology we promise you an extraordinary event. Admission is free!

2nd Annual Population PK-PD
23 September 2010 - 24 September 2010

Integrating advanced PK/PD models with systems biology to make early impacts in the decision making process.
This annual marcus evans conference will be focusing on overcoming these challenges by understanding from a technology and concept perspective on how to marry the distinct practices of PKPD and systems biology.

Cyprotex 6th North American Drug Discovery Workshop
23 September 2010 - 23 September 2010

Following the success of our previous workshops, we are pleased to announce our 6th North American event which features a number of outstanding speakers in the ADMET/DMPK field to present on a range of relevant topics and specific approaches to ADMET within the industry.
  


MS Binding Assays - A New Concept for Drug Screening

Klaus Wanner, Full Professor, Ludwig- Maximilians-University Munich, speaking at Screening Europe 2009


Pharmacological Characterization of GPRC6A – A 7TM Receptor Activated by L-a-Amino Acids and Positively Modulated by Divalent Cations

Petrine Wellendorph, Associate Professor, University of Copenhagen, speaking at Screening Europe 2009

Preclinical Models: Innovative solutions to accelerate drug discovery and development
Business Insights

Preclinical models are developed to test lead compounds for toxicity and efficacy. They are valuable tools for minimizing development costs and reducing failures prior to the commencement of human trials. Problems with traditional animal models such as cost, ethics and suitability have prompted researchers to develop new models and systems to overcome these disadvantages.

Stem Cells Market Trends 2010: Drug Discovery/Toxicity Screening and Regenerative Medicine
Select Biosciences Ltd

This market trends report from Select Biosciences presents the results from our latest industry tracking completed in March 2010. The data presented herein are based on primary market surveys from a worldwide respondent pool of industry participants active in the stem cells field.

MycoAlert Mycoplasma Detection Assay (Lonza) on the SpectraMax® L Microplate Luminometer
Molecular Devices

Mycoplasma infections are costly to the cell culturist as they change the morphology, viability and metabolism of the contaminated cells. Mycoplasmas are the smallest and simplest prokaryotes and depend entirely on their hosts for many nutrients due to their limited biosynthetic capabilities. Cell culture contamination by mycoplasma is difficult to detect as it does not produce pH changes or turbidity, and culture with antibiotics does little to deter this “invisible” menace.

Quantitating Double-Stranded DNA with Quant-iT PicoGreen dsDNA Reagent and SpectraMax® Fluorescence Microplate Readers
Molecular Devices

Double-stranded DNA is typically quantitated in microplate readers by measuring the absorbance of the DNA solution at 260 nm. However, this method is only able to measure down to about 250 ng/mL on a typical absorbance microplate reader. For biological applications involving small samples, such as purification of DNA fragments for subcloning and quantitation of DNA amplification products, more sensitive methods are needed. The Quant-iT PicoGreen dsDNA Assay from Molecular Probes (Invitrogen) is