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Coagulation, AstraZeneca, and Johnson & Johnson Vaccines. What do we know?

The COVID-19 vaccine, Astra Zeneca and Johnson & Johnson, may contribute to blood clots very rarely. Find out what we know about these vaccines.

  1. What do we know about blood clots after taking AstraZeneca?
  2. What do we know about blood clots after administering the Johnson & Johnson vaccine?
  3. What do we know about AstraZeneca and Johnson & Johnson vaccines?
  4. What can cause a blood clot?
  5. Vector vaccinated or not vaccinated?

The European Medicines Agency (EMA) has confirmed that there is a link between the administration of AstraZeneca and Johnson & Johnson COVID-19 vaccines and the development of blood clots. However, the risk is extremely rare (one dose is taken in 100,000 doses) and the risk of dying from the disease is lower (1 in every million doses taken). Hence, the EMA endorsed the recommendations for these vaccines and concluded that the benefits of administering them outweigh the risks of potential complications, but instructing manufacturers to mention thrombosis in the package insert as a very rare side effect of vaccination.

What do we know about blood clots after taking AstraZeneca?

The European Medicines Agency announced that 34 million doses have already been administered in the European Economic Area (European Union, Iceland, Norway, and Liechtenstein) and the United Kingdom. Astra Zeneca Vaccines. Symptoms of thrombosis have been reported in 222 subjects, of whom 18 died (data from 03/22/2021). Cerebral venous sinus thrombosis (CVST), most often in the abdominal veins or arteries.

In patients who have developed venous sinus thrombosis in the brain, this is called thrombocytopenia, which is a decrease in the number of platelets responsible for blood clotting in the bloodstream.

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Most of the reported cases were in women under 60 years of age with symptoms of a blood clot within two weeks of vaccination.

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Symptoms of blood clots after vaccination

What do we know about blood clots after administering the Johnson & Johnson vaccine?

In the United States, where 6.8 million people were vaccinated with Johnson & Johnson, vaccinations have been suspended with the vaccine (pending clarification) due to 6 reported cases of blood clots. In all cases, cerebral venous sinus thrombosis was associated with thrombocytopenia. This disease appeared in women between the ages of 18 and 48. One of them died.

What do we know about AstraZeneca and Johnson & Johnson vaccines?

The COVID-19 vaccines AstraZeneca and Johnson & Johnson are based on the same technology – they are vector vaccines.
They use active viruses – adenoviruses – modified in a way that reduces the risk of infection. They can be vaccine viruses that have been shown to be effective and safe in the past, or viruses that cannot cause disease in humans.

AstraZeneca Chimpanzee Adenovirus, Johnson & Johnson Select Human Adenovirus.

These vectors, i.e. harmless viruses, after entering the human cell are able to produce select proteins of the pathogen against which the body’s immune response must be directed. These types of vaccines induce a strong immune response even at a low dose, but they do not cause disease because the vector viruses used cannot replicate. This trains the immune system to be ready for live coronavirus.

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AstraZeneca is given in two doses, several weeks apart. The Johnson & Johnson vaccine is a single dose vaccine.

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Venous thrombosis

Associated Press / East News

What can cause a blood clot?

The researchers noted that the mechanism of clot formation after some COVID-19 vaccines is not known. Some of them, however, refer to the “culprit”, that is, adenoviruses.

– Although there is a causal relationship between some Vaccination against COVID-19, platelet abnormalities and blood clots have not been confirmed, the professor said. Eleanor Reilly, Immunologist at the University of Edinburgh.

Peter Marks of the US Food and Drug Administration said that the “possible cause” of clots could be the body’s abnormal response to vaccines.

According to the researchers, the coagulation mechanism after administration of a vaccine carrier may be similar to the coagulation mechanism after administration of … the anticoagulant low molecular weight heparin. In very rare cases, heparin-induced thrombocytopenia (Thrombocytopenia caused by heparin – hits). It is for this reason that the Food and Drug Administration concluded that although heparin is commonly used to treat blood clots, administering this drug may be dangerous in this condition.

The EMA called for more research.

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Symptoms of a blood clot - 8 alarming signs

Symptoms after AstraZeneca

Vector vaccinated or not vaccinated?

Vaccinate yourself. Because the benefits of vaccination outweigh the risks of developing a blood clot. COVID-19 vaccines protect against the severe course of disease and reduce the risk of death. The EMA has maintained its recommendations on these vaccines, but said it leaves the decision on vaccination kits to individual states.

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a. Krzysztof J. Filipak. In an interview with Piata Lubica on the “Gość Radio ZET” broadcast, he said: – In a healthy young woman, who does not suffer from comorbidities, who uses hormonal oral contraceptives, the risk of stroke is – Attention! – 500 times higher than a person vaccinated with AstraZeneca. Is this a reason to withdraw hormonal oral contraceptives in the world? Another example. Some common medications, such as heparin, increase the risk of blood clots 100 times more than those used with AstraZeneca. However we are talking about a drug that is supposed to act as an anticoagulant! In general, it is easier to get a blood clot using hormonal contraceptives or heparin compared to AstraZeneca. So please do not be afraid of this vaccine.

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Source: medicalxpress.com/ BBC News